Champix is effective in smoking cessation as a result of its partial positve
activity at the α4β2 nicotinic receptor where its binding produces an effect sufficient to alleviate
symptoms of craving and withdrawal (agonist activity), while simultaneously resulting in a reduction of
the rewarding and reinforcing effects of smoking by preventing nicotine binding to α4β2 receptors
(antagonist activity).
When taking champix for 12 weeks, 44% of over 2000 people in 2 official trial did not smoke at all for
the last 4 weeks and 22% did not smoke at all up until a year after the start of the trial even though
champix was not taken after week 12. This quit rate was more than twice as good than if no medicines
were taken, and champix was shown to be significantly better than zyban (bupropion). Champix was shown
to reduce the craving and withdrawal and also reduced the pleasure from smoking.
It has also been shown that if champix is taken for a further 12 weeks (24 weeks in total) 70% of over
600 patients did not smoke at all in the 24 week period.
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Champix should only be taken if prescribed by a registered doctor. Champix should only be taken by
adults over 18 years and should not be taken if you are pregnant. A lower dose may be needed if you have
a problem with your kidneys. Please tell your doctor or pharmacist if you are taking or have recently
taken any other medicines, including medicines obtained without a prescription. The effects of changes
in your body resulting from stopping smoking, with or without treatment with champix, may alter the way
other drugs work. Therefore, in some cases an adjustment of the dose may be necessary. Examples include
theophylline (a medicine to treat breathing problems), warfarin (a medicine to reduce blood clotting),
and insulin (a medicine to treat diabetes). If in doubt, you should consult your doctor or pharmacist.
For some people stopping smoking has been associated with an increased chance of experiencing feelings
such as depression and anxiety. You may temporarily experience increased irritability, urge to smoke,
depression and/or sleep disturbances when you stop taking champix. Your doctor may decide to gradually
lower your dose of champix at the end of treatment.
Champix can cause side effects. The most common are headache, difficulty sleeping, abnormal dreams and
Nausea. Other common side effects are increased appetite, changes in the way things taste, dry mouth,
sleepiness, tiredness, dizziness, vomiting, constipation, diarrhoea, feeling bloated, stomach discomfort,
indigestion, flatulence.
Always take champix exactly as your doctor has told you. Before starting your course of champix you
should decide on a date in the second week of treatment (between day 8 and day 14) when you will stop
smoking. You should write this date on the pack as a reminder.
The usual dose for adults which you should follow from Day 1 is described in the following table:
Week 1
Day 1 - 3: From day 1 to day 3, you should take one white
champix 0.5 mg film-coated tablet once a day.
Day 4 - 7: From day 4 to day 7, you should take one white champix 0.5 mg film-coated tablet twice daily,
once in the morning and once in the evening, at about the same time each day.
Week 2
Day 8 - 14: From day 8 to day 14, you should take one light
blue champix 1 mg film-coated tablet twice daily, once in the morning and once in the evening, at about
the same time each day.
Weeks 3-12
Day 15 - end of treatment: From day 15 until the end of
treatment, you should take one light blue champix 1 mg film-coated tablet twice daily, once in the
morning and once in the evening, at about the same time each day.
Should you experience adverse effects that you cannot tolerate your doctor may decide to reduce your
dose temporarily or permanently to 0.5 mg twice daily. After 12 weeks of treatment, if you have
stopped smoking, your doctor may recommend an additional 12 weeks of treatment with CHAMPIX 1 mg
film-coated tablets twice daily.